Authors Affiliation(s)
- NIMHANS, Bangalore 29, INDIA
Can J Biotech, Volume 1, Special Issue, Page 87, DOI: https://doi.org/10.24870/cjb.2017-a74
Presenting author: vikasnimhans@yahoo.com
Abstract
Some studies have reported parental consanguinity as a risk factor for schizophrenia. These finding need replication in different socio-cultural settings. Hence we studied inbreeding to examine its effect on susceptibility to schizophrenia. A case-control study was conducted among people living in a rural community at Turuvekere (SZ, n = 120; controls, n = 222). The prevalence of consanguinity was estimated from family history data (‘self report’), followed by DNA analysis using SNPs (n = 384) (‘DNA-based’ rates) in order to add substantial reliability to our data. Self reported parental consanguinity was elevated among the patients (SZ: 10.71%, controls: 7.69%). Tests for normality of the DNA based estimates for coefficients of inbreeding ‘ f ’ showed that ‘ f ‘ was not normally distributed. Mann-Whitney U test showed parental consanguinity rates are significantly elevated among the patients relative to the healthy individuals (p = 0.035). Our data suggest that schizophrenia is associated with higher parental consanguinity. Larger cross-sectional studies are warranted to validate our findings.
References
- Mansour, H., Fathi, W., Klei, L., et al. (2010) Consanguinity and increased risk for schizophrenia in Egypt. Schizophr Res 120: 108-112. Crossref
- Dobrusin, M., Weitzman, D., Levine, J., Kremer, I., Rietschel, M., Maier, W. and Belmaker, R.H. (2009) The rate of consanguineous marriages among parents of schizophrenic patients in the Arab Bedouin population in Southern Israel. World J Biol Psychiatry 10: 334-336. Crossref